Disclosed is a compound of formula (A) or (F) where the substituents are as disclosed in the specification. Examples of compounds of formula (A) or (F) are: (R)-1-(3-(3-(Cyclohexylmethoxy)phenyl)-3-hydroxypropyl)guanidine； 1-(3-(Cyclohexylmethoxy)benzyl)guanidine and (3-(2-Propylpentyloxy)phenyl)methanamine. Also disclosed is a pharmaceutical composition comprising a compound of formula (A) or (F) and the use of a compound in the manufacture of a medicament for treating an ophthalmic disease or disorder in a subject such as retinal detachment, haemorrhagic retinopathy, retinitis pigmentosa, cone-rod dystrophy, Sorsby's fundus dystrophy, optic neuropathy, inflammatory retinal disease, diabetic retinopathy, diabetic maculopathy, retinal blood vessel occlusion, retinopathy of prematurity, or ischemia reperfusion related retinal injury, proliferative vitreoretinopathy, retinal dystrophy, hereditary optic neuropathy, uveitis, a retinal injury, a retinal disorder associated with Alzheimer's disease, a retinal disorder associated with multiple sclerosis, and a retinal disorder associated with Parkinson's disease.
