The Government of the United States of America as represented by the Secretary of the Department of
发明人:
Dimiter S. Dimitrov,Xiaodong Xiao,Ira H. Pastan
申请号：
US15012023
公开号：
US20160145338A1
申请日:
2016.02.01
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed herein are isolated human monoclonal antibodies that specifically bind human CD22 with a dissociation constant (Kd) of 25 nM or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. The antibodies can be used to detect human CD22 in a sample. In some cases, CD22 is soluble CD22. Methods of diagnosing a B-cell malignancy, or confirming a B-cell malignancy diagnosis, are disclosed herein that utilize these antibodies. Methods of treating a subject with a B-cell malignancy are also disclosed.
