This disclosure relates to for treating and/or preventing autoimmune fibrosis, such as systemic sclerosis (SSc Chorionitis) method and composition. This method includes giving a effective amount of death receptor agonists to subject in need. Suitable death receptor agonists include tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL), exciting death receptor antibodies and its variant, analog or derivative. This of the death receptor agonists gives blocking fibroblast or promotees fiber generation cell activation and/or reduction or exhaust myofibroblast, and then reduction or prevention system sclerosis.
