CONJUGUE DE CIBLAGE POLYMERE A BRAS MULTIPLES ANTICANCEREUX

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专利权人:

LTD.;BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO.

发明人:

YUAN, JIANDONG,HUANG, YANGQING,SONG, YUNSONG,YUAN, FANG

申请号：

CA3024371

公开号：

CA3024371A1

申请日:

2017.05.15

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

Disclosed is a multi-arm targeting drug coupling agent modified by a water-soluble polymer； the drug coupling agent has the structural formula of (III). In formula (III), R is an organic center, POLY is a polymer, L is a polyvalent linker, T is a targeting molecule, D is a camptothecin drug, and q is any integer between 3 and 8. The drug conjugate can improve the poor water solubility, high toxicity and low bioavailability of camptothecin drugs.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/