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SILK FIBROIN AND POLYETHYLENE GLYCOL-BASED BIOMATERIALS
专利权人:
David L. Kaplan
发明人:
David L. Kaplan,Monica A. Serban
申请号:
US13820440
公开号:
US20130287742A1
申请日:
2011.09.01
申请国别(地区):
US
年份:
2013
代理人:
摘要:
This invention relates to methods and compositions for preparation of silk-PEGs based biomaterials through crosslinking by chemically reacting active polyethylene glycols (PEGs) possessing different chemical groups (e.g., thiols and maleimides functionalized PEGs) that are additionally stabilized by the beta-sheet formation of silk fibroin. The crosslinked silk-PEGs biomaterials present strong adhesive properties, which are comparable to or better than the current leading PEG-based sealant, depending on the silk concentration in the silk-PEGs biomaterials. In addition, the silk-PEGs based biomaterials are cytocompatible, show decreased swelling behavior and longer degradation times, which make them suitable for hemostatic applications where the current available tissue sealant products can be contraindicated.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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