The present invention discloses a compound, its tautomers, stereisomers, or pharmaceutically acceptable saults, and also discloses its applications in medicine preparations for curing FXR-related diseases. The compound has a structure as shown in Formula I, Formula II, Formula III, Formula IV, or Formula V.本申請公開了式Ⅰ、式Ⅱ、式Ⅲ、式Ⅳ或式Ⅴ所示化合物、其互變異構體、其立體異構體或其藥學上可接受的鹽,並公開了其在製備治療FXR相關疾病藥物中的應用。無