The instant application relates to deazapurines, thienopyrimidines and furopyrimidines with zinc-binding moiety based derivatives and their use in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase.本發明係關於具有以鋅連接部位為基礎之衍生物的氮雜嘌呤(deazapurine)、噻吩並嘧啶(噻吩pyrimidine)與furopyrimidine及其使用於治療磷酸肌醇3-激酶相關疾病及病症，如癌症。本申請案更關於組織蛋白去乙醯酶(histone deacetylase,HDAC)相關病症與關於組織蛋白去乙醯酶及磷酸肌醇3-激酶兩者之疾病的治療。
