A new and distinct grapevine plant named ‘Sheegene 25’, characterized by the following unique combination of characteristics: ‘Sheegene 25’ a cultivar developed as a table grape having berries that are large, red, and seedless. The large berries are approximately 7 g each naturally and without girdling or application of plant growth regulators. Harvest is during August when maturity reaches 17-22° brix.