PURPOSE: A pharmaceutical composition containing a mixture of Lentinula edodes extract, chlorpheniramine, and betamethasone is provided to prevent and treat viral diseases.CONSTITUTION: A pharmaceutical composition for preventing and treating diseases contains Artemisiae asiaticae Herba and Lentinula edodes extract, chlorpheniramine(C_16H_19CIN_2, C_4H_4O_4), tramadol, and betamethasone as an active ingredient. The virus includes enterovirus VSV virus, HBV virus, HIV virus, and RNA virus. The composition contains 0.1-80 wt% of the extract and 99.9% or more of chlorpheniramine.COPYRIGHT KIPO 2013[Reference numerals] (AA) Adding 1700 ml of 0.75% saline solution and basalt to Artemisiae asiaticae Herba(Kg/1) + Lentinula edodes(Kg/1) and heating, adding germanium gemstone and tourmaline gemstone dried by sunlight for one day, supplying 9.2V and 2.6-3A of direct current for 8 hours, inserting anions and far infrared ray elementary particles to liquid at 60-80 Deg. C., and purifying liquid: Step 1(process 1) (BB) Adding Chlorpheniramine Maleate to first extract and shaking (process 2) (CC) Adding Tramadol Hydrochloride to second extract and shaking (process 3) (DD) Adding beta-methasone to second and third mixture and finally shaking (process 4)본 발명은 우수한 항바이러스 활성을 나타내는 표고버섯(Lentinula edodes)추출물과 클로르페니라민(Chlorpheniramine Maleate), 베타메타손(Betamethasone)을 배합하여, 바이러스 질환의 예방 및 치료 약학조성물 및 면역력을 증가시켜주는데 목적이 있다