Interfering RNA duplex having blunt-ends and 3-modifications

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专利权人:

发明人:

申请号：

EP12151831.0

公开号：

EP2489737A1

申请日:

2004.08.27

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention relates to double-stranded RNA compounds with at least one blunt end comprising at least one 3-end of formulawherein R5 and R6 are the same or different and are H or alkyl, wherein alkyl can be substituted by an additional heteroatom selected from the group of N, O, S, or a functional group selected from the group OH, NH2, SH, carboxylic acid or ester and wherein R5 and R6 are not both H and wherein said double-stranded RNA mediates RNA interference.

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