Kodina Galina Evgenevna,Кодина Галина Евгеньевна,Malysheva Anna Olegovna,Малышева Анна Олеговна,Klementeva Olga Evgenevna,Клементьева Ольга Евгеньевна,Lyamtseva Elena Aleksandrovna,Лямцева Елена Алекс
申请号：
RU2016141851
公开号：
RU0002624237C1
申请日:
2016.10.26
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: pharmacology.SUBSTANCE: set of reagents and a solution of sodium perrhenate, 188Re obtained from 188W/188Re generator is prepared. First, a set of lyophilized reagents is prepared, consisting of two vials of lyophilized reagents. Vial 1 contains lyophilized tin dichloride, dihydrate and stabiliser. Vial 2 contains a lyophilized neutralizing agent to adjust acidity. Radio pharmaceutical composition for radiosynovectomy is synthesized. First, a sodium perrhenate solution, 188Re, from 188W/188Re generator is obtained. For elution, an 0.9% isotonic sodium chloride solution for injection is used. Then 1.0 ml of sodium perrhenate solution 188Re, with a volume activity of 37 to 1850 MBq/ml is introduced into vial 1. The resulting suspension is stirred. Kept at the room temperature for 1 hour. Then 2.5 ml of 0.9% isotonic sodium chloride solution for injection is injected into vial 2 and stirred. After complete dissolution of the lyophilized agent, a syringe is used to remove all content from vial 2 and inject it into vial 1, the formed suspension is stirred, obtaining a radio pharmaceutical composition for radiosynovectomy ready for application, the pH value of the finished composition is 3.2-5.9, radiochemical purity exceeds 90%, output of labelled particles with dimensions of 2-10 µm is more than 80%. A radio pharmaceutical composition for radiosynovectomy is proposed as well.EFFECT: homogeneous distribution of the radio pharmaceutical composition in the intra-articular space for 72 hours without causing an inflammatory reaction.6 cl, 8 tbl, 3 exГруппа изобретений относится к медицине и может быть использована для получения радиофармацевтической композиции для радиосиновэктомии. Для этого готовят набор реагентов и раствор натрия перрената, 188Re, получаемого из генератора 188W/188Re. Сначала приготавливают набор лиофилизированных реагентов, состоящий из двух флаконов с лиофилизированными реагентами. Флакон 1 содержит лиофилизированные олова дихлорид дигидрат и ста
