antibody Formulations

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专利权人:

Novartis AG

发明人:

Brisbane, Charlene E,Ketkar, Amol Sharad,Lashmar, Ulla Tove

申请号：

DK15155712

公开号：

DK2889310T3

申请日:

2008.07.03

申请国别(地区):

DK

年份:

2018

代理人:

摘要：

This invention relates to a shear and temperature stable antibody formulations that are more stable than compared to a standard formulation (such as 30 mM citrate, 100mM NaCl, pH 6.5). The present invention's shear and temperature stable antibody formulations show reduced precipitation when subjected to stress conditions but the standard formulation had aggregated. This result was unpredictable because thermodynamically the two formulations are similar as seen by their DSC (differential scanning calorimeter) profiles.

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中国工程科技知识中心

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