THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND;RANNEY, JESSE
发明人:
RANNEY, JESSE,HORN-RANNEY, ELAINE,KHOSHAKHLAGH, PARASTOO,MOORE, MICHAEL
申请号：
CA2877725
公开号：
CA2877725A1
申请日:
2013.06.28
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Otologic materials and methods are provided. For example, a cell-adhesive, biodegrable hydrogel scaffold loaded with time-released drugs for repairing chronic tympanic membrane perforations is disclosed, methods of making same and administering same are provided. This hydrogel may promote vascular in-growth and pithelial cell growth of the tympanic membrane with the purpose of closing the perforation and providing a barrier between the external and middle ear. The hydrogel is initially a liquid polymer that only gels upon exposure to specific conditions, such as exposure to light. This scaffold may simultaneously induce repair of the tympanic membrane while preventing or alleviating middle ear infection, thus filling a void in current tympanic membrane perforation therapies.
