COLLINS, MARY,WOOD, CLIVE R.,CARRENO, BEATRIZ M.,VALGE-ARCHER, VIIA,LUXENBERG, DEBORAH,JUSSIF, JASON,RUSSELL, CAROLINE,CARTER, LAURA L.,BENNETT, FRANCES K.,ANDREWS, JOHN
申请号：
CA2508660
公开号：
CA2508660C
申请日:
2003.12.22
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
This disclosure provides antibodies and antigen-binding fragments that can actas agonists and/or antagonists of PD-1 (Programmed Death 1), therebymodulating immune responses in general, and those mediated by TcR and CD28, inparticular. The disclosed compositions and methods may be used for example, intreating autoimmune diseases, inflammatory disorders, allergies, transplantrejection, cancer, and other immune system disorders.
