The present invention provides a pharmaceutical composition comprising quinoline derivative. Specifically, the present invention provides a process for preparing a pharmaceutical composition comprising (R, E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidinyl-2-yl)-acrylamide or a pharmacologically acceptable salt thereof. The process for preparing is suitable for large-scale industrial production, and the obtained sample has the characteristics such as rapid and uniform dissolution.
