Joseph E. Payne,Padmanabh Chivukula,Priya Karmali,Steven P. Tanis
申请号：
US15387067
公开号：
US20180169268A1
申请日:
2016.12.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
What is described is a compound of formula Iconsisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons； R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons； L1 and L2 are the same or different, each a linear alkylene of 1 to 20 carbons or a linear alkenylene of 2 to 20 carbons； X1 is S or O； R3 is a linear or branched alkylene consisting of 1 to 6 carbons； and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons； or a pharmaceutically acceptable salt thereof.
