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Method of inhibiting bacterial growth and biofilm formation with natural quorum sensing peptides
专利权人:
Steven D. Goodman
发明人:
Steven D. Goodman,Olga Kay,Wenyuan Shi,Fengxia Qi
申请号:
US11561275
公开号:
US09127045B2
申请日:
2006.11.17
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Methods for selectively manipulating a growth rate of a selected bacterium comprising the step of contacting the selected bacterium with a predetermined amount of a quorum sensing molecule to affect a change in the growth rate of the selected bacterium, wherein the quorum sensing molecule is species specific, and the change in the growth rate is dependent on the amount of quorum sensing molecule in a dose-dependent fashion. Also provided are methods for treating or protecting against bacterial infections by utilizing the dose-dependent response of bacterial quorum sensing systems. The methods can be applied to a wide range of bacteria species including Streptococci, Staphylococci, and Bacilli. Compositions, medicaments and oral formulations for use with the methods are also disclosed.
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