A medical device includes a tube, at least one imaging sensor coupled to an endoscope in the tube, and a monitor application to monitor positioning of the tube in a medical patient by identifying expected anatomical features in images provided by the at least one sensor. A method for endotracheal intubation includes receiving imaging frames from a sensor located in an endotracheal tube inserted through a patients mouth, and processing the imaging frames to identify a progression of anatomical features consistent with a proper placement of the endotracheal tube.