The present invention concerns a substantially purified agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof for use in a method for increasing the development of one or more structures selected from the group consisting of hair follicle, tooth, sweat gland, sebaceous glands, larynx and trachea mucus-producing cells, Meibomian glands, preputial glands, mammary glands and salivary glands in a tissue.
