Gary Brian Evans,Alistair Ian Longshaw,Vern L. Schramm,Peter Charles Tyler
申请号：
US15347944
公开号：
US09957272B2
申请日:
2016.11.10
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (1) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.
