Active pharmaceutical preparations and combinations of pharmaceutical ingredients are also available. 1. Claim 1: a formula compound (1),or a pharmaceutically acceptable salt thereof, wherein R¹ represents phenyl, C₄₋₇ cycloalkenyl or Het¹,This R1 group cannot be replaced with r74911 or replaced with one or two carbon atoms；It can also be replaced by r7491 in nitrogen atom； 1each Rᵃ independently represents C₁₋₄ alkyl,halo, haloalkyl C₁₋₄,cyano, C₁₋₄ hydroxyalkyl,C₁₋₄ alkoxy,haloalcoxilo C₁₋₄,C₁₋₄-C₁₋₄- alkoxy,R OC (O) -o R OC (O) alquilo C -R7491； 1 for apartment c832131；Calcium hydroxide c83216c831832424；C₁₋₄-C₁₋₄- alkoxy,alquil C aminoalquilo C -of [alquil C₁₋₄] aminoalquilo C₁₋₄-,aril-alquilo C - o R OC (O) alquilo C -R2 stands for lease No. c83217c831832626；C₃₋₇ cycloalkyl,cycloalkenyl C₄₋₇,2. For phenyl, furan, sulfuryl hydrazide, Tianjin or pyrazole, r74955 shall not be replaced with one or three carbon atoms；and it can also be substituted in a nitrogen atom by C₁₋₄ alkyl；each Rᵇ independently represents C₁₋₄ alkyl,halo, haloalkyl C₁₋₄,ciano alquil C aminoalquilo C -di- [alquil C₁₋₄] aminoalquilo C₁₋₄-,(R⁶) ₂NC (O) C₁₋₄- alkyl R⁶OC (O) C₁₋₄- alkyl；X for O, NH or nm； or X for - ch832222-o,wherein the atom O is fixed to the atom -C (R⁴) (R⁴) of the ring； each R³ independently represents methyl or ethyl； R⁴ represents hydrogen, C₁₋₄ alkyl,C₁₋₄ haloalkyl,Calcium hydroxide c83216c831832424；C₁₋₄-C₁₋₄- alkoxy,aminoquilo C₁₋₄-,alquil C aminoalquilo C -of [alquil C₁₋₄] aminoalquilo C₁₋₄-,1. Fenilo, heth1 asphalt c832131；Het² alquilo C₁₋₄,alquil C S (O) NH-alquilo C -o R⁷C(O)NH-alquilo C₁₋₄-；R830808 for H or methyl； r8308； 74919 for hydrogen, c83231 / 8324；C₁₋₄ haloalkyl,aminoquilo C₁₋₄-,alquil C aminoalquilo C -of [alquil C₁₋₄] aminoalquilo C₁₋₄-,Het1 - lessor c8321c8318324a -,Het²-alquilo C₁₋₄-o R OC (O) -R83100b is hydrogen, c8332131 matrix 832431；R⁷ represents C₁₋₂ alkyl,C₁₋₂ alkoxy,a. Alcox c832183316c83216o fenilo； het 1 represents a heterocycle of 5 or 6 member
