The multiport vitrectomy cutter (10) is an ocular surgical tool allowing a surgeon to select between a single cutting port configuration and a multiple cutting port configuration. The multiport vitrectomy cutter includes an internal tube (36) and a rotating external tube (22). The external tube has a plurality of external ports (28, 30, 32) for receiving vitreous of the eye. The internal tube (36) has a closed distal end (38), defining a cutting blade, and is slidably disposed within the external tube (22) so that the cutting blade oscillates across a first one of the external ports (28) to cut tissue. The internal tube (36) has at least one internal port (40, 42), such that selective rotation of the external tube (22) with respect to the internal tube (36) selectively aligns the at least one internal port (40, 42) with a remainder of the external ports (30, 32).