이준엽,신윤재,류상록,LEE, JOON YOUBKR,SHIN, YOUN JAEKR,RYU, SANG ROKKR
申请号：
KR1020150008575
公开号：
KR1020150014530A
申请日:
2015.01.19
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a nanoemulsion ophthalmic composition that has enhanced solubility of cyclosporine, which is an active ingredient, and has improved stability of the ophthalmic composition by mixing cyclosporine, a water-insoluble solvent, an emulsifier and a water-soluble solvent； and to a manufacturing method thereof. The nanoemulsion ophthalmic composition according to the present invention has an average particle size equal to or less than 200 nm, desirably equal to or less than 100 nm, and has a very narrow particle distribution. Therefore, the nanoemulsion ophthalmic composition can be used usefully for eye drop as sterile filtration is enabled, stability is improved and the composition has effects of clinically mitigating foreign material sensation and cloudy vision.본 발명은 사이클로스포린, 비수성용제, 유화제, 수성용제를 혼합함으로써 유효성분인 사이클로스포린의 용해도를 증가시키고 점안 조성물의 안정성을 개선시킨 나노에멀젼 점안조성물 및 이의 제조방법에 관한 것이다. 본 발명에 따른 나노에멀젼 점안조성물은 평균 입자 크기가 200nm 이하 바람직하게는 100nm 이하이며, 입자 분포가 매우 좁은 특징이 있다. 따라서, 제균여과가 가능하고 안정성이 개선되며 임상적으로 이물감 및 시야흐림 개선효과가 우수하므로 안구 점안용으로 유용하게 사용될 수 있다.
