MANNION, RICHARD OWEN,ODONNELL, EDWARD PATRICK,MCKENNA, WILLIAM HENRY,HUANG, HAIYONG HUGH
申请号：
NZ59776007
公开号：
NZ597760A
申请日:
2007.08.24
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
597760 Disclosed is a solid oral extended release pharmaceutical dosage form comprising an extended release matrix formulation, the extended release matrix formulation comprising a composition comprising at least: (1) at least one polyethylene oxide having, based on rheological measurements, a molecular weight of at least 900,000 and (2) at least one active agent selected from opioid analgesics and wherein the composition comprises at least about 80 % (by wt) polyethylene oxide having, based on rheological measurements, a molecular weight of at least 900,000, and wherein a molecular weight of 900,000 corresponds to a viscosity range of 8,800 to 17,600 mPa s (cP) as measured in a 5% (by wt) aqueous solution of said polyethylene oxide using a Brookfield viscometer Model RVF, spindle No. 2, at 2 rpm and at 25 degree C Also disclosed is the use of the dosage form in the manufacture of a medicament for the treatment of pain. Further disclosed is the use of polyethylene oxide that has a molecular weight of at least 900,000, corresponding to a viscosity range of 8,800 to 17,600 mPa s (cP), as matrix forming material in the manufacture of a solid extended release oral dosage form comprising an active agents elected from opioids for imparting to the solid extended release oral dosage form resistance to alcohol extraction.
