José Angel Martínez Escribano,Andrés Wigdorovitz,Félix Gil Dones,Agustin Ostachuk,Mariano Pèrez Filguera,Javier Dominguez,Carmen Núnez Serrano,Maria Josè Dus Santos,Covadonga Alonso Marti
申请号：
US12922287
公开号：
US08557246B2
申请日:
2008.03.14
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Fusion protein with directioning of vaccinal antigens toward antigen-presenting cells and the applications thereof. This invention relates to a gene construct that comprises, operatively bound, at least one nucleotide sequence (A) that encodes a polypeptide with SEQ ID NO: 1, which has a region that recognizes the β chain of the class-II DR antigen present on the surface of antigen-presenting cells and one nucleotide sequence (B) that encodes a vaccinal antigen of interest. Moreover, this invention relates to recombinant vectors useful for the expression of the gene construct of the invention, transgenic cells and plants transformed or transfected with said vectors, fusion proteins encoded by the gene construct of the invention and vaccines that comprise said fusion proteins.
