PROTUTIJELO KOJE PREPOZNAJE ČIMBENIK INHIBICIJE LJUDSKE LEUKEMIJE (LIF) I UPOTREBA PROTUTIJELA PROTIV LIF U LIJEČENJU BOLESTI POVEZANIH S NEPOŽELJNOM STANIČNOM PROLIFERACIJOM
Fundacio Privada Institut d'Investigacio Oncologica de Vall D'Hebron (VHIO);Fundació Privada Institució Catalana De Recerca I Estudis Avançants
发明人:
Seoane Suarez, Joan,Folgueira, Judit Anido,Saez Borderias, Andrea
申请号：
HRP20161736
公开号：
HRP20161736T1
申请日:
2016.12.16
申请国别(地区):
HR
年份:
2017
代理人:
摘要：
The invention relates to antibodies directed against human Leukemia Inhibitory Factor (LIF) and to a hybridoma cell line producing said antibodies. The invention also relates to a method for blocking/inhibiting the proliferation of stem cells, and to an in vitro method for the diagnosis of diseases associated with unwanted cell proliferation in a subject or for determining the predisposition of a subject to suffer said disease associated with unwanted cell proliferation, or for prognosis of average life expectancy of a subject suffering from said disease. The therapeutic potential of said antibodies is based on observing that the inhibition of LIF can be used in therapeutic compositions for the treatment of diseases associated with unwanted proliferation.
