The present invention relates to antibodies that broady neutralize interferon-α and interferon-ω, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.ANTICUERPOS MONOCLONALES QUE SE UNEN ESPECÍFICAMENTE A INTERFERON ALFA Y OMEGA; ÁCIDOS NUCLEICOS; VECTORES; CÉLULAS HUÉSPEDES; COMPOSICIONES FARMACÉUTICAS Y USOS PARA EL TRATAMIENTO DEL LUPUS ERITOMATOSO