Methods for treating cancer (e.g. breast cancer lung cancer pancreatic cancer primitive neuroectodermal tumors lung cancer ovaria cancer endometrial cancer pharyngeal cancer esophageal cancer and sarcoma) in a subject (such as an human patient) in need thereof by administering eribulin (e.g. eribulin mesylate i.e. E7389 Halaven) in combination with one or more mammalian target of rapamycin (mTOR) inhibitors (e.g. everolimus ridaforolimus and temsirolimus) and kits therefor are provided.