#$%^&*AU2013202932A120130502.pdf#####H:\aar\Intenvoven\NRPortbl\DCC\AAR\5054850_ .DOC-8/04/2013 ABSTRACT The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP. 113b