HEALD, ROBERT,PRICE, STEPHEN,DO, STEVEN,FOLKES, ADRIAN J.,BLAQUIERE, NICOLE,HEFFRON, TIM,GOLDSMITH, RICHARD A.,KOLESNIKOV, ALEKSANDR,NDUBAKU, CHUDI,OLIVERO, ALAN G.,STABEN, STEVEN,WEI, BINQING,DUDLEY,
申请号：
PE0015582013
公开号：
PE09182014A1
申请日:
2010.09.27
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Relates to compounds of formula (i) wherein: Z1 or Z2 is CR1 and CR2 is n n n is Cr3 or Z3 Z4 CR4 is o n x1 and x2 is CR7 is s s or x1 and x2 is CR7 r1 is H, F, CL, BR, I, CN, CF3, NO2 and c1-c4 alkyl R2, R3, R4 and R7 are independently h, F, CL, BR, I, CN, among others C6 C20 is aryl, heter Ociclilo heteroaryl C1 - C2 - C20 and C20, optionally substituted with F, CL, BR, I, CN, among others.Are preferred compound: 2 - [2 - (2.4 - difluoro - phenyl) - 2H - [1,2,4] triazol yl] - 3 - 9 - (4 - methyl - piperazin-1-yl) - 4,5-dihydro - oxa - 1 - 6 - 10 - tia - aza benzo [e] Azulene 1 - {2 - [2 - (2.4 - difluoro - phenyl) - 2H - [1,2,4] triazol yl] - 3 - oxa 4,5-dihydro - 6 - 10 - - 1 - - Aunt AZA benzo [e]} - Blue - 9il piperidin-4-ol among others.It also refers to a Pharmaceutical composition containing Said compound and an additional Therapeutic Agent, such as antiviral agents, chemotherapy, among others. These compounds are useful for the treatment of disorders such as cancer hiperproliferativosSE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: Z1 ES CR1 O N Z2 ES CR2 O N Z3 ES CR3 O N Z4 ES CR4 O N X1 ES CR7 Y X2 ES S O X1 ES S Y X2 ES CR7 R1 ES H, F, Cl, Br, I, CN, CF3, NO2 Y ALQUILO C1-C4 R2, R3, R4 Y R7 SON INDEPENDIENTEMENTE H, F, Cl, Br, I, CN, ENTRE OTROS A ES ARILO C6-C20, HETEROCICLILO C2-C20 Y HETEROARILO C1-C20, OPCIONALMENTE SUSTITUIDOS CON F, Cl, Br, I, CN, ENTRE OTROS. SON COMPUESTO PREFERIDOS: 2-[2-(2,4-DIFLUORO-FENIL)-2H-[1,2,4]TRIAZOL-3-IL]-9-(4-METIL-PIPERAZIN-1-IL)-4,5-DIHIDRO-6-OXA-1-TIA-10-AZA-BENZO[e]AZULENO 1-{2-[2-(2,4-DIFLUORO-FENIL)-2H-[1,2,4]TRIAZOL-3-IL]-4,5-DIHIDRO-6-OXA-1-TIA-10-AZA-BENZO[e]AZULEN-9IL}-PIPERIDIN-4-OL ENTRE OTROS. SE REFIERE ADEMAS A UNA COMPOSICION FARMACEUTICA QUE CONTIENE DICHO COMPUESTO Y OTRO AGENTE TERAPEUTICO ADICIONAL TAL COMO, AGENTES ANTIVIRALES, QUIMIOTERAPEUTICOS, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS HIPERPROLIFERATIVOS COMO EL CANCER
