The Research Foundation of State University of New York;Amgen Inc.
发明人:
Malone, James P.,Paxton, Raymond J.,Hanel, Walter,Wittekind, Michael,Kramer, Jill,Gaffen, Sarah L.,Shen, Fang
申请号：
AU2008242665
公开号：
AU2008242665B2
申请日:
2008.04.20
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptidescomprising an amino acid sequence of a domain (e.g., a Fibronectin Ill-like domain)of an IL-17 Receptor (IL- 17R) family member, wherein the PLAD polypeptide inhibitsmultimerization of a receptor complex comprising an IL- 17R family member. Alsoprovided are isolated PLAD- binding polypeptides, e.g., antibodies and avimers,which specifically bind to a PLAD polypeptide described herein. Related chimericproteins, conjugates, nucleic acids, vectors, and host cells are provided herein.Further provided are methods of treating an inflammatory or autoimmune disease,methods of inhibiting IL-17-mediated signal transduction, methods of inhibitingIL-17 ligand binding, methods of inhibiting multimerization of IL-17R complexes,and methods of inhibiting the production of at least one cytokine, chemokine,matrix metalloproteinase, or other molecule associated with IL-17 signal transductionare provided.
