CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS

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专利权人:

MERCK SHARP & DOHME CORP.

发明人:

CARRINGTON, PAUL, E.,DENG, QIAOLIN,NARGUND, RAVI,PALANI, ANANDAN,TUCKER, THOMAS JOSEPH,WU, CHENGWEI,BIANCHI, ELISABETTA,ORVIETO, FEDERICA,PESSI, ANTONELLO

申请号：

SG11201703238T

公开号：

SG11201703238TA

申请日:

2015.10.22

申请国别(地区):

SG

年份:

2017

代理人:

摘要：

Described are peptide analogs of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have relatively balanced agonist activity at the glucagon-like peptide 1 (GLP-1) receptor and the glucagon (GCG) receptor, and the use of such GLP-1 receptor/GCG receptor co-agonists for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.

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