Arne Staby;Thomas Budde Hansen;Janus Krarup;Haleh Ahmadian;Anne Charlotte Arentsen;Susanne Bang;Daniel E. Rasmussen;Are Bogsnes
发明人:
Janus Krarup,Thomas Budde Hansen,Anne Charlotte Arentsen,Daniel E. Rasmussen,Are Bogsnes,Arne Staby,Haleh Ahmadian,Susanne Bang
申请号：
US11722644
公开号：
US09187549B2
申请日:
2005.12.23
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.
