The present invention provides a supramolecular protein assembly useful as aproteintherapeutics for the treatment of metabolic disorders particularly diabetes.The supramolecularprotein assembly disclosed in the present invention consists of insoluble andaggregatedoligomers the protein. The invention also provides pharmaceutical compositionscomprisingsupramolecular protein assembly. The composition disclosed in the presentinvention particularlycomprises supramolecular insulin assembly.