An exemplary surgical method of treating tissue within the body of a patient may include having an endocutter having an end effector inserting the end effector into the body of a patient through an opening engaging tissue with the end effector stapling tissue along two staple lines with the end effector cutting tissue between the staple lines with the end effector releasing the tissue from the end effector and repeating the engaging, stapling, cutting and releasing within the body of the patient on tissue at a different location within the body of the patient while maintaining the end effector within the body of the patient. Another exemplary surgical method of treating a plurality of discrete tissue structures within the body of a patient in which an incision has been made may include having an endocutter that holds a plurality of staples inserting the distal end of the endocutter through the incision in the patient and transecting a plurality of the discrete tissue structures with the distal end of the endocutter, without withdrawing the distal end of the endocutter through the incision in the patient and without inserting additional staples into the endocutter.