A biopsy device includes a sample receiving notch formed in an elongate member. The sample receiving notch defines a side port adjacent the outer surface. The sample receiving notch extends inwardly from the side port toward a longitudinal axis and terminates at a sample floor in an interior of the elongate member. The sample receiving notch has a proximal end wall separated from a distal end wall along the longitudinal axis. The floor extends between the proximal end wall and the distal end wall. A tissue anchor has a cantilever portion and a head portion at a free end of the cantilever portion. The cantilever portion extends from a distal portion of the elongate member adjacent to the sample receiving notch toward the proximal end wall of the sample receiving notch. The head portion has a sharp tip that extends from the cantilever portion toward the sample floor.