Provided is a process for preparing a polyurethane foam dressing in which an anti-inflammatory agent is homogeneously dispersed, the process including obtaining a drug (i.e., anti-inflammatory agent)-containing polyurethane prepolymer using a certain dispersing agent; and reacting the drug-containing polyurethane prepolymer with a water-containing blowing solution to form a polyurethane foam and then drying the polyurethane foam.