Methods and compositions for treating autoimmune disorders by targeting Kv1.3 ion channels with functionalized lipid-derived nanovesicles

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专利权人:

发明人:

Laura Conforti,Yeoheung Yun

申请号：

US14863525

公开号：

US09777279B2

申请日:

2015.09.24

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased expression and/or hyperactivity of T cells by selectively targeting memory T cells with the nanoparticles, which deliver their siRNA cargo into the cytosol of the TM cell thus reducing ion channel expression and decreasing Ca2+ influx.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/