Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.L'invention concerne des composés, des compositions et des méthodes pour traiter des maladies et des troubles, dans lesquels un inhibiteur de la kinase, tel que la rho kinase (ROCK), et un inhibiteur d'un ou de plusieurs transporteurs de monoamines, tels que NET ou SERT, agissent conjointement pour améliorer le trouble.
