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Use of azabicyclo hexane derivatives
专利权人:
Glaxo Group Limited
发明人:
Melotto, Sergio,Hamprecht, Dieter,Micheli, Fabrizio,Heidbreder, Christian,Yamada, Tadataka
申请号:
AU2006284077
公开号:
AU2006284077B2
申请日:
2006.08.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The present invention provides a new use of a compound of formula (I) or a pharmaceuticallyacceptable salt or solvate salt thereof, wherein: G is selected from a group consistingof: phenyl, pyridyl, benzothiazolyl, indazolyl; p is an integer ranging from0 to 5; R is independently selected from a group consisting of: halogen,hydroxyl, cyano, C1-4alkyl, haloC1-4alkyl, C alkoxy, haloCalkoxy,Calkanoyl; or corresponds to a group R; Ris hydrogen or C alkyl; R I s Calkyl; Ris hydrogen, or a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromaticgroup, or a 8- to 11-membered bicyclic group, any of which groups is optionallysubstituted by 1, 2, 3 or 4 substituents selected from the group consisting of:halogen, cyano, Calkyl, haloCalkyl, Calkoxy,Calkanoyl; R is a moiety selected from the group consistingof: isoxazolyl, -CH-N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl,thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and such a group is optionallysubstituted by one or two substituents selected from: halogen, cyano, Calkyl,haloCalkyl, Calkoxy, Calkanoyl;and when R is chlorine and p is 1, such R is not present inthe ortho position with respect to the linking bond to the rest of the molecule;and when R corresponds to R, p is 1; in the manufacture ofa medicament for the treatment of a somatoform disorder such as body dysmorphicdisorder or hyperchondriasis, bulimia nervosa, anorexia nervosa, binge eating,paraphilia and nonparaphilic sexual addictions, Sydeham's chorea, torticollis,autism, a movement disorder including Tourette's syndrome; and in themanufacture of a medicament for the treatment of premature ejaculation.
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