In a first aspect, a monoplace hyperbaric chamber providing Venturi induced gas circulation and ventilation is disclosed. The chamber includes a control and monitoring system that offers reduced oxygen consumption, duplex pressure gauges, referenced flow control, a patient activated stop function, an independent pressure time recorder, and/or a precise pressure control circuit that uses a 1:1 forced-balanced volume amplifier adapted to supply gas to and exhaust gas from the chamber through different penetrators and/or use flow-control check valves supplied with static reference or set pressures. A computer control and monitoring subsystem is also disclosed. Numerous other aspects are provided.