The present Invention provides novel protease resistant polypeptides and compositions and Methods for treating, ameliorating or Preventing Joint damage Related Conditions, including acute injury of joints and arthritisLa presente invencion proporciona nuevos polipeptidos resistentes a la proteasa, asi como composiciones y metodos para tratar, mejorar o prevenir condiciones relacionadas con dano articular, incluyendo lesion aguda de articulaciones y artritis