High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences

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专利权人:

SELEXIS S.A.

发明人:

MERMOD NICOLAS,Mermod Nicolas,GIROD PIERRE ALAIN,Girod Pierre Alain,BUCHER PHILIPP,Bucher Philipp,CALABRESE DAVID,Calabrese David,NGUYEN DUC-QUANG,Nguyen Duc-Quang,SAUGY DAMIEN,Saugy Damien,PUTTINI ST

申请号：

SI200432011

公开号：

SI2287302T1

申请日:

2004.10.22

申请国别(地区):

SI

年份:

2013

代理人:

摘要：

The present invention relates to purified and isolated DNA sequences having protein production increasing activity and more specifically to the use of matrix attachment regions (MARs) for increasing protein production activity in a eukaryotic cell. Also disclosed is a method for the identification of said active regions, in particular MAR nucleotide sequences, and the use of these characterized active MAR sequences in a new multiple transfection method.

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