NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL ANDDENTAL UNIVERSITY
发明人:
TAMAMURA, HIROKAZU,NAKAHARA, TORU,NOMURA, WATARU
申请号：
EP10777543
公开号：
EP2444414A4
申请日:
2010.05.14
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
An object of the present invention is to provide an HIV antibody-inducing peptide antigen that can be used without problems for HIV, which is highly prone to mutation, and is effective in developing an antibody or a vaccine having excellent specificity and binding activity even for the three-dimensional structure of a neutralization target, i.e. the mechanism by which HIV invades a target cell a method for synthesizing the same a vaccine comprising the peptide antigen, or an HIV three-dimensional structure-recognizing antibody induced by the peptide antigen and a preventive and/or therapeutic agent for HIV infection comprising the peptide antigen, the vaccine, or the HIV three-dimensional structure-recognizing antibody as an active ingredient. The synthesis method comprises using a trimer of N36 peptide derivative which is synthesized by ligating a derivative of a helical region N36 peptide in N-terminal of an HIV particle transmembrane protein gp41 to a C3-symmetric template compound having three equivalent linker structures.
