JOHN MICHAEL BEALS,GORDON BUTLER ER,BRANDON DOYLE,RYAN JOHN HANSEN,SHUN LI,SHAHRIAR SHIRANI,LIANSHAN ZHANG
申请号：
PT09763419
公开号：
PT2288375E
申请日:
2009.06.09
申请国别(地区):
PT
年份:
2012
代理人:
摘要：
The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.
