Bernhard Suppmann;Werner Hoelke;Artur Hoffmann;Thomas Marx;Kirsten Sonn;Johann-Peter Thalhofer
发明人:
Bernhard Suppmann,Werner Hoelke,Artur Hoffmann,Thomas Marx,Kirsten Sonn,Johann-Peter Thalhofer
申请号：
US12478306
公开号：
US08236356B2
申请日:
2009.06.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides improved media for the cultivation of Clostridium histolyticum and culture supernatants for the biotechnological production of collagenase enzymes. The nutrient media according to the invention comprise one or more peptones from a non-mammalian source, preferably plant-derived peptones. The media can additionally comprise fish gelatin. The invention provides media, culture supernatants comprising Clostridium histolyticum collagenase, and methods to produce said collagenase.
