REPUBLIC OF KOREA(ANIMAL AND PLANT QUARANTINE AGENCY);BIOPOA, INC.;대한민국(농림축산식품부 농림축산검역본부장);주식회사 바이오포아
发明人:
CHO, Sun-Hee,조선희,PARK, Changhoon,박창훈,BAEK, Jong Hyuk,백종혁,CHA, Sang Ho,차상호,KANG, Seok-Jin,강석진,YOU, Suhwa,유수화,CHO, In-Soo,조인수
申请号：
KRKR2019/017319
公开号：
WO2020/138761A1
申请日:
2019.12.09
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a chimeric virus of porcine reproductive and respiratory syndrome (PRRS) virus, the chimeric virus being usable as a vaccine. A PRRSV chimeric virus of the present invention is more attenuated than the parent strain thereof, and thus promotes the secretion of neutralizing antibodies while having low pathogenicity and high stability, thereby being usable as a vaccine in the effective prevention and treatment of PRRS diseases.La présente invention concerne un virus chimère du virus du syndrome reproducteur et respiratoire porcin (PRRS), le virus chimère peut être utilisée comme vaccin. Le virus chimère de PRRSV selon la présente invention est plus atténué que sa souche parente, et favorise ainsi la sécrétion d'anticorps de neutralisation tout en ayant une faible pathogénicité et une stabilité élevée, ledit virus chimère peut ainsi être utilisé en tant que vaccin pour la prévention et le traitement efficaces de maladies de PRRS.본 발명은 백신으로 사용할 수 있는 돼지생식기 및 호흡기 증후군(PRRS) 바이러스의 키메라 바이러스에 관한 것이다. 본 발명의 PRRSV 키메라 바이러스는 모균주보다 약독화되어 있어 병원성이 낮고 안정성이 높으면서, 중화항체의 분비를 향상시켜 PRRS 질환의 효과적인 예방 및 치료용 백신으로 사용할 수 있다.
