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ANTI-MN ANTIBODIES AND WAYS OF THEIR APPLICATION
专利权人:
БАЙЕР ХЕЛЬСКЕР ЛЛСИ (US)
发明人:
ТАМБУРИНИ Пол (US),РЕЙНДЖИС Джеральд (US),ЭДНЕЙН Лайла (US),МАККЕЙБ Тимоти (US),ТРЕЙЛ Памела (US),ХА Ша (US)
申请号:
RU2011126596/15
公开号:
RU2011126596A
申请日:
2011.06.29
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. An antibody or antibody fragment having an antigenic binding site specifically directed against an MN protein, wherein the antigenic binding site includes at least one CDR1, CDR2 or CDR3: (a) said CDR1 is selected from the group consisting of SEQ ID NOS : 57, 58, 59, 60, 61, 62, 77, 80, 81, 86, 87, 88, 89, 98, 99, 104, 107, 108 and an amino acid sequence having approximately more than 80% identity of any of the SEQ sequences ID NOS: 57, 58, 59, 60, 61, 62, 77, 80, 81, 86, 87, 88, 89, 98, 99, 104, 107 or 108; (b) said CDR2 is selected from the group consisting of SEQ ID NOS: 63, 64, 65, 66, 67, 68, 69, 78, 82, 83, 90, 91, 92, 93, 100, 101, 105, 109, 110 and am an acid sequence having about 80% identity with any of the sequences of SEQ ID NOS: 63, 64, 65, 66, 67, 68, 69, 78, 82, 83, 90, 91, 92, 93, 100, 101, 105, 109 or 110; (c) said CDR3 is selected from the group consisting of SEQ ID NOS: 70, 71, 72, 73, 74, 75, 76, 79, 84, 85, 94, 95, 96, 97, 102, 103 , 106, 111, 112 and an amino acid sequence having about 80% identity with any of the sequences of SEQ ID NOS: 70, 71, 72, 73, 74, 75, 76, 79, 84, 85, 94, 95, 96, 97 , 102, 103, 106, 111 or 112.2. The antibody or antibody fragment of claim 1, wherein the antigen binding site comprises a heavy chain variable region CDR selected from the group consisting of: SEQ ID NOS: 57-85 and an amino acid sequence having about 80% identity with any of the sequences of SEQ ID NOS : 57-85.3. The antibody or antibody fragment of claim 1, wherein the antigen binding site comprises a light chain variable region CDR selected from the group consisting of: SEQ ID NOS: 86-112 and an amino acid sequence having about 80% identity with any of the sequences of SEQ ID NOS : 86-112.4. An antibody or antibody fragment according to claim 1, wherein the antigenic binding site comprises a set of CDR sequences1. Антитело или фрагмент антитела, имеющие сайт антигенного связывания, специфично направленный против MN-протеина, где сайт антигенного связы
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