Since the compound having a quinoline skeleton represented by the general formula (I) has a strong Axl inhibitory activity, it can be used as an active ingredient of Axl related diseases such as acute myelogenous leukemia, chronic myelogenous leukemia, melanoma, breast cancer, pancreatic cancer, glia A cancer such as a tumor, a kidney disease, an immune system disease, and a cardiovascular disease.一般式（Ｉ）で示されるキノリン骨格を有する化合物は、強力なＡｘｌ阻害活性を有することから、Ａｘｌ関連疾患、例えば、急性骨髄性白血病、慢性骨髄性白血病、メラノーマ、乳癌、膵臓癌、神経膠腫等の癌、腎臓疾患、免疫系疾患、循環器系疾患の治療剤となり得る。
