596244 Disclosed is a method of enhancing the activity of PP2A in a cell comprising administering to the cell an effective amount of selenate or a pharmaceutically acceptable salt thereof, wherein the cell is in vitro. Further disclosed is a method for inhibiting the activity of GSK3b in a neuron or glial cell, comprising exposing the cell to an effective amount of selenate or a pharmaceutically acceptable salt thereof, wherein the cell is in vitro.